• Associate Scientist, Analytical Development

    Posted Date 7 days ago(10/9/2018 12:05 PM)
    Job ID
    2018-3211
    # of Openings
    1
    Job Location(s)
    US-MD-Gaithersburg
    Category
    Research
  • Overview

    Medical Science & Computing (MSC) is an exciting growth oriented company, dedicated to providing mission critical scientific and technical services to the Federal Government. We have a distinguished history of supporting the National Institutes of Health (NIH) and other government agencies. MSC offers a dynamic and upbeat work environment, excellent benefits and career growth opportunities.

     

    We attract the best people in the business with our competitive benefits package that includes medical, dental and vision coverage, 401k plan with employer contribution, paid holidays, vacation, Medical and Flexible Spending Accounts, Pre-Tax Transit Assistance and tuition reimbursement. If you enjoy being a part of a high performing, professional service and technology focused organization, please apply today!

     

    Duties & Responsibilities

    Medical Science & Computing is searching for an Associate Scientist, Analytical Development to provide support to the National Institutes of Health (NIH).  This opportunity is a full-time position with MSC and it is on-site in Gaithersburg, Maryland.

    • This position will work, or lead an HPLC or mass spec subgroup within Analytical Development department of the Labs. This demanding position will significantly contribute to the clinical development of a variety of vaccine candidates and therapeutic biomolecule drug candidates. This includes development of assays for virus vaccines, recombinant proteins and virus-like particles, and some monoclonal antibodies, that may be used as clinical vaccine candidates or therapeutic antibody treatment.
    • Primary responsibilities will include method development, optimization, qualification, and testing support. This job also include tech transfer, investigations, writing GLP/GMP documentation including procedure, designing protocol, technical reports, and IND enabling support for bio-separation assays and mass spec based assays for cGMP product release and characterization. This is a hands on and/or leadership position. The candidate must have demonstrated experience in the development of the following assays for cGMP product characterization and release of clinical material

     

     

    Requirements

    • Bachelor’s degree, Master’s degree or PhD in Life Sciences or related discipline. The hiring level will be commensurate with the level of experience.
    • For Associate scientist levels: B.S. and M.S. minimal and relevant experiences
    • Solid understanding of protein chemistry and protein characterization methods. Prior cGMP assay development experience in a pharmaceutical or biotech environment setting is required. Experience in analysis of protein expression and proteomics characterization is highly desirable. Experience with analytical equipment automation will be highly beneficial.
    • A thorough understanding of protein analysis with experience in quantitative and qualitative protein analysis for assay development is required. Knowledge of the requirements and experience developing, qualifying and/or validating assays for cGMP products and managing method transfers between laboratories is required. The candidate will be involved in developing, characterizing and transferring assays to the Lab pilot plant’s QC group for product release.
    • Strong working knowledge and proficiency with protein characterization using chromatography and/or mass spectrometry
    • Release assay development on HPLC/UPLC (Waters preferred)
    • Mass spec assays including intact mass analysis, peptide mapping, disulfide mapping, post-translation modifications include glycan structure analysis
    • Quantitative assays such as, LC-MS and HPLC (RP, IEX, and SEC)
    • Qualitative /quantitative electrophoresis assays including SDS-PAGE, IEF and Western Blot
    • Proven data presentation, troubleshooting and problem solving skills
    • Familiarity of vaccine / therapeutic protein development and regulatory requirements such as GLP/GMP practices
    • Ability to implement new methods and technologies, particular in compliant environment
    • Understanding of experimental objectives and experimental design, including a successful track record of independently performing experiments and consistently preparing accurate and complete experimental records
    • Excellent organizational, oral and written communication skills, including a customer-focused attitude
    • The ability and desire to work comfortably in a fast paced team setting, collaborate with other groups and deliver results in line with project and team objectives
    • Team player

     

     

    Medical Science & Computing is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status.

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