• Protein Design Research Scientist

    Posted Date 3 months ago(7/26/2018 12:17 PM)
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  • Overview

    Medical Science & Computing (MSC) is an exciting growth oriented company, dedicated to providing mission critical scientific and technical services to the Federal Government. We have a distinguished history of supporting the National Institutes of Health (NIH) and other government agencies. MSC offers a dynamic and upbeat work environment, excellent benefits and career growth opportunities.


    We attract the best people in the business with our competitive benefits package that includes medical, dental and vision coverage, 401k plan with employer contribution, paid holidays, vacation, Medical and Flexible Spending Accounts, Pre-Tax Transit Assistance and tuition reimbursement. If you enjoy being a part of a high performing, professional service and technology focused organization, please apply today!


    Duties & Responsibilities

    Medical Science & Computing is searching for a Protein Design Research Scientist to support the National Institutes of Health (NIH). This opportunity is full-time, and it is on-site in Bethesda, MD. 


    Duties & Responsibilities:

    • Leverage the plethora of structural data available for malaria antigens and antigen-antibody complexes to design novel immunogens. The individual will employ established computational methods, devise novel immunogen design strategies, and convert designs into viable immunogens.
    • Structurally define neutralizing antibody epitopes in key malaria antigens. The candidate will have experience using structural and biophysical approaches to study antibody-antigen complexes. He/she will assist in the study of the human antibody response to malaria.
    • It is increasingly clear that malaria parasites use diverse host-parasite and vector-parasite interactions to ensure parasite survival. The structures of these complexes are poorly defined and the lack of this fundamental information hampers current efforts to design vaccines that will prevent critical interactions. The candidate will assist is the structure determination and biophysical characterization of key complexes.


    Position Requirements

    • Ph.D. or an M.D./Ph.D. with 5+ years of experience in malaria structural biology.
    • Experience with protein design, cryo-electron microscopy and/or x-ray crystallography.
    • Demonstrated track record of successful protein production and purification for structural studies.
    • Experience with immunogen design, antibody-antigen complexes and host-pathogen complexes is very desirable.
    • Experience with biophysical approaches including small angle x-ray scattering, bio-layer interferometry, or analytical ultracentrifugation would be helpful.
    • Experience with in vitro and in vivo parasite growth assays would be beneficial but not required.

    Medical Science & Computing is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status.


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